Fachbereich 16



Prof. Dr. rer. nat. Donat Kögel

Experimental Neurosurgery
Neuroscience Center
Frankfurt University Clinics
Theodor-Stern-Kai 7
D-60590 Frankfurt am Main

Tel ++49 69-6301-6923
Fax ++49 69- 6301-5575









Scientific Focus


Our research mainly focuses on the molecular mechanisms of apoptosis, non-apoptotic cell death and autophagy. In one part of our studies, we are elucidating the molecular events leading to gliomagenesis, as well as apoptosis deficiency and therapy resistance of glioblastoma multiforme, the most malignant and deadly human primary brain tumor. Based on these investigations, we are trying to develop novel genetic insight-based therapeutic strategies for the treatment of gliomas in cell culture models and in transplantable syngeneic animal tumor models. Another major aim in our lab is to identify the relevant pathophysiological stress stimuli and cell death signalling pathways implicated in apoptotic neuron death in stroke, Alzheimer´s disease and Parkinson´s disease. In this context, we are especially interested in the transcriptional stress responses and mitochondrial events underlying cell death and cell survival decisions in neurons.



Research Interests


Mechanisms of programmed cell death, acute and chronic cns damage, neuronal stress signalling, physiological and pathophysiological roles of the amyloid precursor protein and its family members, mitochondrial control of cell death, target-specific therapies for the treatment of brain tumors, oncogenic signalling pathways, autophagy in health and disease, mechanisms of tumor cell migration and invasion.



Major Current Projects



1. Mechanisms of autophagy-dependent cell death in apoptosis-deficient cancers

zum SFB Teilprojekt

2. STAT3 and Pim-1 as therapeutic targets for the treatment of glioma


3. Investigating the role of APP family members in stress signalling and aging

4. The TF/PAR-2 pathway in glioma







German Research Foundation (DFG)

German Cancer Aid (Deutsche Krebshilfe)

LOEWE program, state of Hessia (OSF)

Alzheimer Forschung Initiative (AFI)







Assays for detection of apoptosis (Caspase assays, FACS Annexin/propidium iodide, measurement of mitochondrial membrane potentials), autophagy (LC3 conversion and translocation, autophagic flux of GFP-LC3-RFP, p62 degradation, FACS Lysotracker) and cell viability (MTT assay), cultivation of primary neurons, in vitro hypoxia/ischemia models, reporter gene assays, siRNA techniques, lentiviral gene transfer, live cell imaging, in vivo brain tumor models, in vitro models for cell migration and invasion.





Group members


Dr. Benedikt Linder Postdoc 49 69-6301-84051
Patrick Antonietti PhD student 49 69-6301-6940
Stefanie Rakel PhD student 49 69-6301-6940
Arpita Kundu PhD student 49 69-6301-6930
Nina Meyer PhD student 49 69-6301-6940
Janina Remy PhD student 49 69-6301-6930
Katharina Arndt Master student 49 69-6301-6940
Julia Konovalova Master student 49 69-6301-6940
Gabriele Köpf technician 49 69-6301-6930
Hildegard König technician 49 69-6301-84051

Cooperation Partners




Prof. Dr. Christian Behl, Institute for Pathobiochemistry, Johannes Gutenberg University Mainz

Prof. Dr. Achim Aigner, Institute of Pharmacology and Toxicology, University of Leipzig

Prof. Dr. Jochen Prehn, RCSI, Dublin, Ireland

Prof. Dr. Ulrike Müller, , Institute of Pharmacy and Molecular Biotechnology, Heidelberg University

Prof. Dr. Stefan Kins, Dept. of Biology, University of Kaiserslautern

Dr. Thorsten Müller, Functional Proteomics, Ruhr University Bochum

Prof. Dr. Andreas von Deimling, Dept. of Neuropathology, Heidelberg University




Dr. Christian Behrends, Inst. of Biochemistry II, Goethe University Frankfurt

Prof. Dr. Michel Mittelbronn, Edinger Institute, Goethe University Frankfurt

Prof. Dr. Simone Fulda, Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt

Prof. Dr. Thomas Deller, Dept. of Clin. Neuroanatomy, Goethe University Frankfurt

PD Dr. Martin Zörnig, Georg Speyer Haus, Frankfurt

Prof. Dr. Heinz Osiewacz, Institute of Molecular Biosciences, Frankfurt

Prof. Dr. Gunter Eckert, Department of Pharmacology, Goethe University Frankfurt

Prof. Dr. Abdelhaq Rami, Dept. of Neuroanatomy, Goethe University Frankfurt

Dr. Francesco Pampaloni, FMLS, Frankfurt

Prof. Dr. Joachim Steinbach, Dept. of Neurooncology, Goethe University Frankfurt






Original papers


Before 2010


Kögel D, Aboud M, Flügel RM. (1995) Molecularbiological characterization of the human foamy virus reverse transcriptase and ribonuclease H domain. Virology 213, 97-108.

Kögel D, Aboud M, Flügel RM. (1995) Mutational analysis of the reverse transcriptase and ribonuclease H domain of the human foamy virus. Nucleic Acids Research 23, 2621-2625.

Kögel D, Plöttner O, Landsberg G, Christian S, Scheidtmann KH. (1998) Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones. Oncogene 17: 2645-2654.

Kögel D, Bierbaum H, Preuss U, Scheidtmann KH. (1999) C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity. Oncogene 18: 7212-7218.

Page G, Kögel D, Rangnekar V, Scheidtmann KH. (1999) Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis. Oncogene 18: 7265-7273.

Page G, Lödige I, Kögel D, Scheidtmann KH. (1999) AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis. FEBS Lett. 462: 187-191.

Poppe M, Reimertz C, Düßmann H, Krohn AJ, Luetjens CM, Bockelmann D, Nieminen AL, Kögel D, Prehn JH.  (2001) Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis. J Neurosci. 21: 4551-4563.

Reimertz C*, Kögel D*, Lankiewicz S, Poppe M, Prehn JH. (2001) Ca2+-Induced Inhibition of Neuronal Apoptosis: Degradation of Apoptotic Protease Activating Factor-1 (APAF-1). J Neurochem. 78: 1256-1266.

Luetjens CM*, Kögel D*, Reimertz C, Düßmann H, Renz A, Schulze-Osthoff K, Nieminen A-L, Poppe M, Prehn JH. (2001) Multiple kinetics of mitochondrial cytochrome c release in drug-induced apoptosis. Mol. Pharm. 60: 1008-1019.

Kögel D, Reimertz C, Mech P, Poppe M, Frühwald M, Engemann H, Scheidtmann KH, Prehn JH. (2001) Dlk/ZIP kinase-induced apoptosis in Human Medulloblastoma Cells: Requirement of the Mitochondrial Apoptosis Pathway. Brit. J Cancer, 85: 1801-1808.

Wobser H, Düßmann H, Kögel D, Wang H, Reimertz C, Wollheim CB, Byrne MM, Prehn JH. (2002) Dominant-Negative Suppression of HNF-1alpha Results in Mitochondrial Dysfunction, beta-cell apoptosis, and Increased Sensitivity to Ceramide-, But Not High Glucose-Induced Cell Death. J. Biol. Chem. 277:6413-6421.

Poppe M, Reimertz C, Münstermann G, Kögel D, Prehn JH. (2002) Ceramide-Induced Cell Death of D283 Medulloblastoma Cells Requires Mitochondrial Respiratory Chain Activity. J. Neurochem. 82:482-494.

Engemann H, Kögel D, Manderscheid S, Preuss U, Scheidtmann KH. (2002) Elucidation of transcriptional elements and the genomic structure of DAP-like kinase.  Ann N Y Acad Sci. 973: 363-367.

Rehm M, Düßmann H, Jänicke R, Tavare JM, Kögel D, Prehn JH. (2002) Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process.  Role of caspase-3.   J Biol Chem. 277: 24506-24514.

Svensson B, Peters M, König HG, Poppe M, Levkau B, Rothermund M, Arolt V, Kögel D, Prehn JH. (2002) VEGF protects cultured rat hippocampal neurons against hypoxic injury. J Cereb Blood Flow Metab. 22: 1170-1175.

Kögel D, Reimertz C, Düßmann H, Mech P, Scheidtmann KH, Prehn JH. (2003) The Death Associated Protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis. Eur J Cancer. 39: 249-256.

Düßmann H, Rehm M, Kögel D, Prehn, JH. (2003) Outer mitochondrial membrane permeabilization during apoptosis triggers caspase-independent mitochondrial and caspase-dependent plasma membrane potential depolarization: a single-cell analysis. J Cell Sci. 116: 525-536.

Düßmann H, Kögel D, Rehm M, Prehn, JH. (2003) Mitochondrial Membrane Permeabilization and Superoxide Production during Apoptosis. A SINGLE-CELL ANALYSIS. J Biol Chem. 278:12645-12649.

Kögel D, Schomburg R, Schürmann T, Reimertz C, Poppe M, Eckert A, Müller WE, Prehn JH (2003). The Amyloid Precursor Protein protects PC12 cells against ER stress-induced apoptosis. J Neurochem. 87: 248-256.

Reimertz C, Kögel D, Rami A, Chittenden T, Prehn JH (2003). Gene Expression during ER Stress-Induced Apoptosis in Neurons: Induction of the BH3-Only Protein Bbc3/PUMA and Activation of the Mitochondrial Apoptosis Pathway. J. Cell Biol. 162: 587-597.

Kögel D, Peters M, König H-G, Hashemi SMA, Bui NT, Arolt V, Rothermundt M, Prehn JHM (2004). S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: Clinical implications for the role of S100B in excitotoxic brain injury. Neuroscience 127: 913-920.

Kögel D, Schomburg R, Copanaki K, Prehn JHM. (2005). Regulation of Gene Expression by the Amyloid Precursor Protein: Inhibition of the JNK/c-Jun Pathway. Cell Death Differ. 12, 1-9.

König H-G, Kögel D, Rami A, Prehn, JHM. (2005). TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J Cell Biol. 168: 1077-1086.

Chandra T, Maier W, König H-G, Hirzel K, Kögel D, Schüler T, Chandra A, Demirhan I, Laube B (2005). Molecular interactions of the HIV-1 Tat protein with NMDA receptor subunits. Neuroscience 134, 145-153.

Gerlach R, Demel G, König H-G, Groß U, Prehn JHM, Raabe A, Seifert V, Kögel D (2006). Active secretion of S100B from astrocytes during metabolic stress. Neuroscience, 141: 1697-1701.

Schultz C, König H-G, Del Turco D, Politi C, Eckert GP, Ghebremedhin E, Prehn JHM, Kögel D, Deller T (2006). Coincident enrichment of phosphorylated IκBα, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci, 33: 68-80.

Kögel D, Svensson B, Copanaki E, Anguissola S, Bonner C, Thurow N, Gudorf D, Hetschko H, Müller T, Peters M, König H-G, Prehn JHM (2006). Induction of Transcription Factor CHOP Mediates Hypoglycemia-Induced Necrotic Cell Death in Human Neuroblastoma Cells. J Neurochem, 99: 952-964.

Concannon CG, Koehler BF, Reimertz C, Murphy BM, Bonner C, Thurow N, Ward MW, Villunger A, Strasser A, Kögel D*, Prehn JHM* (2007). Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway. Oncogene, 26: 1681-1692.

Müller T, Concannon CG, Ward MW, Kögel D, Prehn JHM, Egensperger R (2007). Modulation of gene expression and cytoskeletal dynamics by the APP intracellular domain (AICD). Mol Biol Cell, 18: 201-210.

Copanaki E, Schürmann T, Eckert A, Leuner K, Müller WE, Prehn JHM*, Kögel D* (2007). The Amyloid Precursor Protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion. BBA Mol Cell Res, 1773: 157-165.

Hetschko H, Voss V, Horn S, Seifert V, Prehn JHM, Kögel D. Pharmacological Inhibition of Bcl-2 Family Members Reactivates TRAIL-induced Apoptosis in Malignant Glioma. J Neuro-Oncol. 86: 265-272.

Hetschko H, Voss V, Senft C, Seifert V, Prehn JH, Kögel D (2008). BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells. Neoplasia. 10: 873-885.

Köhler B, Anguissola S, Concannon CG, Rehm M, Kögel D, Prehn JH (2008). Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects. PLoS ONE. 3: e2844.

Anguissola S, Köhler B, O'Byrne R, Düssmann H, Cannon MD, Murray FE, Concannon CG, Rehm M, Kögel D, Prehn JH (2009). Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells. Mol Pharmacol. 76: 998-1010.

Peters I, Igbavboa U, Schütt T, Haidari S, Hartig U, Rosello X, Böttner S, Copanaki E, Deller T, Kögel D, Wood WG, Müller WE, Eckert GP (2009). The interaction of beta-amyloid protein with cellular membranes stimulates its own production. BBA Biomembranes. 1788: 964-972.



Copanaki E, Chang S, Vlachos A, Tschäpe JA, Müller UC, Kögel D*, Deller T* (2010). sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress. Mol Cell Neurosci. 44: 386-393.

Klinkenberg M, Thurow N, Gispert S, Ricciardi F, Eich F, Prehn JH, Auburger G, Kögel D (2010). Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress. Neuroscience. 166: 422-434.

Gessler F, Voss V, Dützmann S, Seifert V, Gerlach R, Kögel D (2010). Inhibition of tissue factor/protease-activated receptor-2 signaling limits proliferation, migration and invasion of malignant glioma cells. Neuroscience. 165:1312- 1322.

Senft C, Polacin M, Priester M, Seifert V, Kögel D, Weissenberger J (2010). The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas. BMC Cancer 10:491.

Voss V, Senft C, Lang V, Ronellenfitsch MR, Steinbach JP, Seifert V, Kögel D (2010). The Pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma.  Mol Cancer Res,  8: 1002-1016.

Weissenberger J, Priester M, Bernreuther C, Rakel S, Glatzel M, Seifert V, Kögel, D (2010). Dietary Curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1, 2/STAT3 signaling pathway. Clin Cancer Res, 16: 5781-5795.



Senft C, Priester M, Polacin M, Seifert V, Kögel D, Weissenberger J (2011). Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells. J Neuro-Oncol. 101: 393-403.

Eckert GP, Chang S, Eckmann J, Copanaki E, Hagl S, Hener U, Müller WE, Kögel D (2011). Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. BBA Biomembranes, 1808: 236-243.

Gessler F, Voss V, Seifert V, Gerlach R, Kögel D (2011). Knockdown of TFPI-2 promotes migration and invasion of glioma cells. Neurosci Lett.497: 49-54.

Bonner C, Farrelly AM, Concannon CG, Dussmann H, Baquié M, Virard I, Wobser H, Kögel D, Wollheim CB, Rupnik M, Byrne MM, König HG, Prehn JH (2011). Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation. J Biol Chem. 286: 25719-25728.




Kögel D, Concannon CG, Müller T, König H, Bonner C, Poeschel S, Chang S, Egensperger R, Prehn JH (2012). The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis. Neurobiol Aging. 33: 2200-2209.




Priester M, Copanaki E, Vafaizadeh V, Hensel S, Bernreuther C, Glatzel M, Groner B, Seifert V, Kögel D, Weissenberger J (2013). STAT3 silencing inhibits glioma single cell infiltration and tumor growth. Neuro-Oncology, 15(7):840-52.

Harter P, Dützmann S, Drott U, Hattingen E, Capper D, Gessler F, Senft C, Seifert V, Plate KH, Kögel D, Mittelbronn M (2013). Anti-tissue factor (TF9-10H10) treatment reduces tumor  cell invasiveness in a novel migratory glioma model. Neuropathology, 33(5):515-25.

Murphy AC, Weyhenmeyer J, Schmid M, Rehm M, Huber HJ, Senft C, Weissenberger J, Seifert V, Kögel D, Prehn JH, Murphy BM (2013). Activation of executioner caspases is a predictor of progression free survival in Glioblastoma Multiforme patients: a systems medicine approach. Cell Death Dis, 16;4:e629.

Eißmann M, Schwamb B, Melzer IM, Moser J, Siele D, Köhl U, Rieker RJ, Wachter RL, Agaimy A, Herpel E, Rakel S, Kögel D, Böhm S, Gutschner T, Diederichs S, Zörnig M (2013). A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes. PLoS One, 8(5):e64873.

Mohrenz I, Voigt S, Senft C, Mukrowsky A, Pusch S, Capper D, Weissert S, Balss J, Seifert V, von Deimling A, Kögel D (2013). Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death. Apoptosis, 18(11):1416-25.



Baumgarten P, Harter PN, Tönjes M, Capper D, Blank AE, Sahm F, von Deimling A, Kolluru V, Schwamb B, Rabenhorst U, Starzetz T, Kögel D, Rieker RJ, Plate KH, Ohgaki H, Radlwimmer B, Zörnig M, Mittelbronn M (2014). Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity. Neuropathol Appl Neurobiol. 40(2): 205-16.

Murphy ÁC, Weyhenmeyer B, Noonan J, Kilbride SM, Schimansky S, Loh KP, Kögel D, Letai AG, Prehn JH, Murphy BM (2014). Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis. Apoptosis. 19(4): 629-42.

Nensa FM, Neumann MH, Schrötter A, Przyborski A, Mastalski T, Susdalzew S, Looβe C, Helling S, El Magraoui F, Erdmann R, Meyer HE, Uszkoreit J, Eisenacher M, Suh J, Guénette SY, Röhner N, Kögel D, Theiss C, Marcus K, Müller T (2014). Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain. Mol Cell Proteomics. 13(2): 475-88.

Fischer S, Ronellenfitsch MW, Thiepold AL, Harter PN, Reichert S, Kögel D, Paschke R, Mittelbronn M, Weller M, Steinbach JP, Fulda S, Bähr O (2014). Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. PLoS One. 9(4): e94921.

Ansari N, Hardung S, Hötte K, Rakel S, Antonietti P, Kögel D, Stelzer EH, Pampaloni F (2014). Quantifying the autophagy-triggering effects of drugs in cell spheroids with live fluorescence microscopy. Methods Mol Biol. 1165:19-29.

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D (2014). Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. Cell Death Dis. 5: e1391.



Afshordel S, Hagl S, Werner D, Röhner N, Kögel D, Bazan NG, Eckert GP (2015). Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging--impact of Bcl-2 and NPD-1 like metabolites. PLEFA. 92: 23-31.

Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P (2015). The cleavage product of amyloid-β protein precursor sAβPPα modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity. J Alzheimers Dis. 44(3): 879-96.

Afshordel S, Kern B, Clasohm J, König H, Priester M, Weissenberger J, Kögel D, Eckert GP (2015). Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation. Pharmacol Res. 91: 69-77.

Mani J, Vallo S, Rakel S, Antonietti P, Gessler F, Blaheta R, Bartsch G, Michaelis M, Cinatl J, Haferkamp A, Kögel D (2015). Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer. 15: 224.

Mani J, Antonietti P, Rakel S, Blaheta R, Bartsch G, Haferkamp A, Kögel D. Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737. World J Urol. 2015 Jun 23. [Epub ahead of print]

Tivnan A, Zakaria Z, O'Leary C, Kögel D, Pokorny JL, Sarkaria JN, Prehn JH (2015). Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 9: 218.

Felzen V, Hiebel C, Koziollek-Drechsler I, Reißig S, Wolfrum U, Kögel D, Brandts C, Behl C, Morawe T (2015). Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function. Cell Death Dis. 6: e1812.

Kiprianova I, Remy J, Milosch N, Mohrenz IV, Seifert V, Aigner A, Kögel D (2015). Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner. Neoplasia. 17(7): 564-73.

Kundu A, Milosch N, Baumkötter F, Müller UC, Kins S, Hajieva P, Behl C, Kögel D (2015). Modulation of BAG3 expression and proteasomal activity by sAPPalpha does not require membrane-tethered holo-APP. Mol Neurobiol. Epub ahead of print.

Zakaria Z, Tivnan A, Flanagan L, Murray DW, Salvucci M, Stringer BW, Day BW, Boyd AW, Kögel D, Rehm M, O’Brien DF, Byrne AT,  Prehn JHM (2015). Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein (IAP) antagonist Birinapant. Brit J Cancer. Epub ahead of print

Antonietti P, Gessler F, Reimertz C, Mittelbronn M, Prehn JH, Kögel D. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localisation of Bcl-xL and Bcl-2 in MCF7 cells. In revision.

Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina E, Jung J, Stadel D, von Renesse J, Drott U, Baumgarten P, Braczysnki AK, Penski C, Burger M, Theurillat JP, Steinbach J, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter P, Mittelbronn M. Diagnostic and clinical relevance of the autophagolysosomal network in human gliomas. In revision.


(* both authors contributed equally to this work)



Reviews and Book Chapters



Kögel D, Prehn JH, Scheidtmann KH. (2001) The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game. Bioessays 23: 352-358.

Kögel D, Prehn JH. (2002) Caspase-independent cell death mechanisms. In: Caspases - their role in cell death and cell survival, edited by M. Los & H. Walczak; Kluwer Press.

Prehn JH, Kögel D (2003). The self-destruction of neurons - physiological and pathophysiological decisions for the functional integrity. In: Brain damage and Repair. From molecular research to clinical therapy, edited by  J.M. Delgado-Garcia and T. Herdegen, Kluwer Press.

Ward MW, Kögel D, Prehn JH. (2004) Neuronal apoptosis: BH3-only proteins the real killers? J Bioenerg Biomembr. 36: 295-298.

Rami A, Kögel D (2008). Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?. Autophagy 4: 422-426.

Kögel D, Fulda S, Mittelbronn M (2010). Therapeutic exploitation of apoptosis and autophagy for glioblastoma. Anticancer Agents Med Chem. 10: 438-449.

Dützmann S, Gessler F, Harter PN, Gerlach R, Mittelbronn M, Seifert V, Kögel D (2010). The pro-migratory and pro-invasive role of the procoagulant tissue factor in malignant gliomas. Cell Adh Migr. 4: 515-522.

Kögel D, Deller T, Behl C. Roles of amyloid precursor protein family members in   neuroprotection, stress signaling and aging (2012). Exp Brain Res. 217: 471-479.

Kögel D. Exploiting BH3 mimetics for cancer therapy. in: Mitochondria: The anti-cancer target for the third millennium (Springer Press, 2015).

Fulda S, Kögel D. Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy. Oncogene. 2015 Jan 26. [Epub ahead of print].






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